Mdfi Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity. Involved in dorsal/ventral axis specification; negative regulation of transcription by RNA polymerase II; and regulation of signal transduction. Acts upstream of or within embryonic skeletal system morphogenesis and trophoblast giant cell differentiation. Located in nucleus. Is expressed in several structures, including medulla oblongata basal plate mantle layer; notochord; sensory organ; skeleton; and trophectoderm. Orthologous to human MDFI (MyoD family inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mdfi |
| Official Name | MyoD family inhibitor [Source:MGI Symbol;Acc:MGI:107687] |
| Ensembl ID | ENSMUSG00000032717 |
| Bio databases IDs | |
| Aliases | MyoD family inhibitor |
| Synonyms | I-MF, I-mfa, MyoD family inhibitor, RGD1560271 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mdfi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- I-mfa-like domain
- transcription factor binding
- MyoD family inhibitor
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
- major depression
- colorectal cancer
- diabetic nephropathy
- growth failure
- epidermal hyperplasia
- dyspnea
- spina bifida
role in cell
- expression in
- differentiation
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mdfi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of DNA binding
- trophoblast giant cell differentiation
- negative regulation of Wnt receptor signaling pathway
- dorsal/ventral axis specification
- cytoplasmic sequestering of transcription factor
- embryonic skeletal system morphogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transcription factor binding