Bmx Gene Summary [Mouse]
Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in B cell receptor signaling pathway; adaptive immune response; and protein autophosphorylation. Predicted to be located in nucleoplasm and ruffle membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; hemolymphoid system; and mammary gland. Orthologous to human BMX (BMX non-receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Bmx |
| Official Name | BMX non-receptor tyrosine kinase [Source:MGI Symbol;Acc:MGI:1101778] |
| Ensembl ID | ENSMUSG00000031377 |
| Bio databases IDs | |
| Aliases | BMX non-receptor tyrosine kinase |
| Synonyms | BMX non-receptor tyrosine kinase, ETK, Etk/Bmx, PSCTK2, PSCTK3, RGD1565643, TYRO8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Bmx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Tec homology domain
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- non-membrane spanning protein tyrosine kinase
- linker domain
- protein binding
- Pleckstrin homology-like domain
- protein-tyrosine kinase
- Protein kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- BTK motif
- tyrosine kinase domain
- PH domain
- Src homology 2 (SH2) domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Bmx gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- breast cancer
- neoplasia
- prostate cancer
- tumorigenesis
- COVID-19
- arthritis
- cardiac hypertrophy
- small cell lung cancer
- chronic inflammation
role in cell
- growth
- accumulation in
- proliferation
- cell death
- apoptosis
- phosphorylation in
- migration
- formation
- differentiation
- extension
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- cytosol
- membrane ruffles
- nucleoplasm
- perinuclear space
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Bmx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- apoptotic process
- mesoderm development
- adaptive immune response
- protein autophosphorylation
- cell adhesion
- phosphatidylinositol biosynthetic process
- protein phosphorylation
- intracellular signal transduction
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- ruffle membrane
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- metal ion binding