Fat3 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Acts upstream of or within generation of neurons; negative regulation of dendrite development; and retina layer formation. Located in dendrite. Is expressed in several structures, including brain; foregut; ganglia; sensory organ; and skeleton. Orthologous to human FAT3 (FAT atypical cadherin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fat3 |
| Official Name | FAT atypical cadherin 3 [Source:MGI Symbol;Acc:MGI:2444314] |
| Ensembl ID | ENSMUSG00000074505 |
| Bio databases IDs | |
| Aliases | FAT atypical cadherin 3 |
| Synonyms | 9430076A06, 9430076A06Rik, CDHF15, CDHR10, D430038H04RIK, FAT atypical cadherin 3, Gm1132, Gm510, hFat3, MFAT3F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fat3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cadherin-like
- LamG
- Human growth factor-like EGF
- Cadherin repeat-like domain
- laminin G domain
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- epithelial neoplasia
- non-insulin-dependent diabetes mellitus
- hepatocellular carcinoma
- liver cancer
- schizophrenia
- peripheral neuropathy
- prostate cancer
- retinal detachment
- postoperative nausea and vomiting
regulates
- CD8 (family)
role in cell
- development
- abnormal morphology
- morphogenesis
- Clathrin mediated endocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fat3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of dendrite development
- retina layer formation
- cell morphogenesis involved in neuron differentiation
- homophilic cell adhesion
- dendrite development
Cellular Component
Where in the cell the gene product is active
- dendrite
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding