Edn2 Gene Summary [Mouse]
This gene encodes a member of the endothelin family of peptides. The encoded preproprotein undergoes proteolytic processing to generate a potent vasoconstrictive peptide. This gene is abundantly expressed in the gastrointestinal tract, strongly induced in photorecepteror cells in retinal diseases and injury, and produced by microglia and macrophages in the early stages of glaucoma. Mice lacking the encoded protein exhibit severe growth retardation, hypothermia and juvenile lethality. [provided by RefSeq, Feb 2016]
Details
| Type | Protein Coding |
| Official Symbol | Edn2 |
| Official Name | endothelin 2 [Source:MGI Symbol;Acc:MGI:95284] |
| Ensembl ID | ENSMUSG00000028635 |
| Bio databases IDs | |
| Aliases | endothelin 2 |
| Synonyms | beta-ET, endothelin 2, ET-2, PPET2, Preproendothelin-2, RNEDN2S01, VIC, β-ET |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Edn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Endothelin family
- G-protein-coupled receptor binding
- hormone
- growth factor
Pathways
Biological processes and signaling networks where the Edn2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypoxia
- growth failure
- androgenic alopecia
- hypercapnia
- acidosis
- congestion
- acidemia
role in cell
- proliferation
- growth
- differentiation
- activation
- invasion
- migration
- chemotaxis
- extension
- stabilization in
- stimulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Edn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of heart rate
- positive regulation of prostaglandin-endoperoxide synthase activity
- positive regulation of cell proliferation
- vasoconstriction
- endothelial cell migration
- positive regulation of the force of heart contraction by chemical signal
- cell tip growth
- hormonal regulation of the force of heart contraction
- macrophage activation
- positive regulation of smooth muscle contraction
- positive regulation of calcium-mediated signaling
- lung alveolus development
- macrophage chemotaxis
- angiogenesis
- cytokine-mediated signaling pathway
- energy homeostasis
- regulation of vasoconstriction
- positive regulation of leukocyte chemotaxis
- cell surface receptor signaling pathway
- regulation of systemic arterial blood pressure by endothelin
- cellular calcium ion homeostasis
- axon extension
- prostaglandin biosynthetic process
- temperature homeostasis
- vein smooth muscle contraction
- neutrophil chemotaxis
- artery smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- endothelin B receptor binding
- hormone activity