Lhx2 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including nervous system development; positive regulation of neural precursor cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including hair follicle development; maintenance of epithelial cell apical/basal polarity; and nervous system development. Located in nucleus. Is expressed in several structures, including branchial arch; future brain; limb primordium; nervous system; and sensory organ. Orthologous to human LHX2 (LIM homeobox 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lhx2 |
| Official Name | LIM homeobox protein 2 [Source:MGI Symbol;Acc:MGI:96785] |
| Ensembl ID | ENSMUSG00000000247 |
| Bio databases IDs | |
| Aliases | LIM homeobox protein 2 |
| Synonyms | ap, apterous, hLhx2, LH2, LH2A, Lim2, LIM homeobox 2, LIM homeobox protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lhx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- nucleic acid binding
- LIM is a small protein-protein interaction domain, containing two zinc fingers
- double-stranded DNA binding
- chromatin binding
- transcription factor binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Pathways
Biological processes and signaling networks where the Lhx2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- nasopharyngeal cancer
- liver cancer
- epithelial cancer
- breast carcinoma
- neoplasia
- hepatitis B virus-related hepatocellular carcinoma
- reactive gliosis
- organismal death
- metastasis
role in cell
- activation
- expression in
- phosphorylation in
- apoptosis
- proliferation
- migration
- invasion by
- growth
- organization
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular space
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lhx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression, epigenetic
- telencephalon regionalization
- retina development in camera-type eye
- neuron differentiation
- mesoderm development
- axon guidance
- cerebral cortex development
- positive regulation of transcription from RNA polymerase II promoter
- olfactory bulb development
- dorsal/ventral pattern formation
- regulation of transcription from RNA polymerase II promoter
- maintenance of epithelial cell apical/basal polarity
- hair follicle development
- neural tube closure
- axon extension
- positive regulation of transcription, DNA-dependent
- positive regulation of neural precursor cell proliferation
- negative regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromatin
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity