Zbtb8a Gene Summary [Mouse]
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in inner cell mass and trophectoderm. Orthologous to human ZBTB8A (zinc finger and BTB domain containing 8A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zbtb8a |
| Official Name | zinc finger and BTB domain containing 8a [Source:MGI Symbol;Acc:MGI:1920930] |
| Ensembl ID | ENSMUSG00000028807 |
| Bio databases IDs | |
| Aliases | zinc finger and BTB domain containing 8a |
| Synonyms | 2410081M15Rik, AI480941, AV220464, BC023839, BOZF1, ZBTB8, zinc finger and BTB domain containing 8A, ZNF916A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zbtb8a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- Broad-Complex, Tramtrack and Bric a brac
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- C2H2-type zinc-finger domain
- BTB_POZ
- BTB/POZ domain
- transcription factor binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zbtb8a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- transcription regulatory region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription coactivator binding