Psmc2 Gene Summary [Mouse]
Predicted to enable TBP-class protein binding activity and proteasome-activating activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body. Part of proteasome accessory complex. Is expressed in several structures, including autopod; frontal process; genitourinary system; and limb bud. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmc2 |
| Official Name | proteasome (prosome, macropain) 26S subunit, ATPase 2 [Source:MGI Symbol;Acc:MGI:109555] |
| Ensembl ID | ENSMUSG00000028932 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, ATPase 2 |
| Synonyms | 19S S7, 26s Protease Regulatory Subunit 7, MSS1, Nbla10058, Proteasome 26s subunit atpase 2, proteasome 26S subunit, ATPase 2, proteasome (prosome, macropain) 26S subunit, ATPase 2, Proteasome (prosome, macropain) 26S subunit, ATPase, 3, PRS7, RPT1, S7 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmc2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- AAA domain (dynein-related subfamily)
- 26S proteasome subunit P45 family
- ATPase family associated with various cellular activities (AAA)
- peptidase
- transcription factor binding
- isomerase
- protein binding
- AAA+ lid domain
- TATA-binding protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Psmc2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- sickle cell anemia
- breast cancer
- non-insulin-dependent diabetes mellitus
- acute graft-vs-host disease
- experimentally-induced diabetes
regulates
- 26S proteasome
- adenosine triphosphate
- WNT
- 19S proteasome
role in cell
- cell death
- apoptosis
- production in
- proliferation
- growth
- activation in
- survival
- migration
- transactivation in
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytoplasmic ribonucleoprotein granule
- cytoplasmic mRNA processing body
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- cytosol
- nucleoplasm
- dendritic spines
- clastosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmc2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- osteoblast differentiation
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- cytoplasm
- membrane
- cytoplasmic mRNA processing body
- cytosol
- secretory granule lumen
- proteasome accessory complex
- proteasome complex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding