Ube3a Gene Summary [Mouse]
Enables transcription coactivator activity and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of TORC1 signaling; positive regulation of Golgi lumen acidification; and proteasome-mediated ubiquitin-dependent protein catabolic process. Acts upstream of or within several processes, including androgen receptor signaling pathway; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and reproductive structure development. Located in cytosol and nucleus. Is active in glutamatergic synapse; postsynaptic cytosol; and synaptic vesicle. Is expressed in several structures, including central nervous system; radius; and retina. Used to study Angelman syndrome. Human ortholog(s) of this gene implicated in Angelman syndrome. Orthologous to human UBE3A (ubiquitin protein ligase E3A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ube3a |
| Official Name | ubiquitin protein ligase E3A [Source:MGI Symbol;Acc:MGI:105098] |
| Ensembl ID | ENSMUSG00000025326 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3A |
| Synonyms | 4732496B02, 5830462N02RIK, A130086L21RIK, ANCR, AS, E6-AP, EPVE6AP, HPVE6A, LOC103691124, PIX1, ubiquitin protein ligase E3A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ube3a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECTc
- transcription co-activator
- Amino-terminal Zinc-binding domain of ubiquitin ligase E3A
- catalytic domain
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Ube3a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- lung adenocarcinoma
- epithelial cancer
- Burkitt lymphoma
- B-cell non-Hodgkin disease
- mature B-cell neoplasia
- Angelman syndrome
- lung adenocarcinoma formation
- breast carcinoma
- hereditary disorder
role in cell
- loss in
- cell death
- expression in
- accumulation in
- number
- migration
- phosphorylation in
- binding in
- activation in
- proliferation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- perinuclear region
- cytosol
- synaptic vesicles
- synaptosomes
- membrane processes
- perikaryon
- dendrites
- apical processes
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ube3a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- locomotory exploration behavior
- response to progesterone stimulus
- regulation of circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- regulation of synaptic plasticity
- positive regulation of protein ubiquitination
- regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- androgen receptor signaling pathway
- sperm entry
- protein autoubiquitination
- negative regulation of dendritic spine morphogenesis
- protein K48-linked ubiquitination
- protein polyubiquitination
- response to cocaine
- prostate gland growth
- response to hydrogen peroxide
- brain development
- ubiquitin-dependent protein catabolic process
- ovarian follicle development
- proteasomal ubiquitin-dependent protein catabolic process
- rhythmic process
- proteolysis
- progesterone receptor signaling pathway
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- proteasome complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- transcription coactivator activity
- metal ion binding