Psma6 Gene Summary [Mouse]
Enables RNA binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in P-body and nuclear matrix. Part of proteasome core complex. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in myocardial infarction. Orthologous to human PSMA6 (proteasome 20S subunit alpha 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psma6 |
| Official Name | proteasome subunit alpha 6 [Source:MGI Symbol;Acc:MGI:1347006] |
| Ensembl ID | ENSMUSG00000021024 |
| Bio databases IDs | |
| Aliases | proteasome subunit alpha 6 |
| Synonyms | 20S PROTEASOME alpha 6 subunit, 20S PROTEASOME α 6 subunit, IOTA, p27K, PROS27, proteasome 20S subunit alpha 6, proteasome 20S subunit α 6, PROTEASOME IOTA CHAIN, proteasome subunit alpha 6, proteasome subunit α 6, PROTEASOME ι CHAIN, ι |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psma6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ntn_hydrolase
- proteasome endopeptidase complex
- Proteasome subunit A N-terminal signature
- NF-kappaB binding
- peptidase
- Proteasome subunit A N-terminal signature Add an annotation
- protein binding
- Proteasome subunit
- RNA binding
Pathways
Biological processes and signaling networks where the Psma6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- susceptibility to myocardial infarction
- psoriasis
- eczema
- chronic kidney disease
- allergy
- leiomyomatosis
regulates
- NFkB (complex)
role in cell
- cell death
- cell viability
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic mRNA processing body
- cilia
- ribosome
- Nucleus
- Mitochondria
- sarcomere
- cytosol
- nucleoplasm
- nuclear matrix
- clastosomes
- myofibrils
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psma6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of inflammatory response
- positive regulation of NF-kappaB transcription factor activity
- proteolysis involved in cellular protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasmic mRNA processing body
- proteasome complex
- ribosome
- nucleoplasm
- nucleus
- extracellular vesicular exosome
- cytoplasm
- proteasome core complex
- proteasome core complex, alpha-subunit complex
- cytosol
- nuclear matrix
- sarcomere
- myofibril
Molecular Function
What the gene product does at the molecular level
- NF-kappaB binding
- RNA binding
- protein binding
- purine ribonucleoside triphosphate binding
- endopeptidase activity