Lnx1 Gene Summary [Mouse]
Enables PDZ domain binding activity; identical protein binding activity; and ubiquitin-protein transferase activity. Involved in synapse maturation. Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in cytoplasm. Is active in hippocampal mossy fiber to CA3 synapse and postsynapse. Is expressed in several structures, including brain; genitourinary system; liver; nasal epithelium; and spleen. Orthologous to human LNX1 (ligand of numb-protein X 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lnx1 |
| Official Name | ligand of numb-protein X 1 [Source:MGI Symbol;Acc:MGI:1278335] |
| Ensembl ID | ENSMUSG00000029228 |
| Bio databases IDs | |
| Aliases | ligand of numb-protein X 1 |
| Synonyms | ligand of numb-protein X 1, LNX, MPDZ, PDZRN2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lnx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain present in PSD-95, Dlg, and ZO-1/2
- zinc finger of C3HC4-type, RING
- canonical PDZ domain
- enzyme
- Ring finger domain
- protein binding
- PDZ domain
- identical protein binding
- PDZ-domain binding
- NPXY motif
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- cpPDZ_Deg_HtrA-like
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- uterine leiomyoma
- leiomyomatosis
- acute myeloid leukemia
- Kawasaki disease
- male pattern hair loss
- dementia
- umbilical hernia
- heart failure
regulated by
role in cell
- development
- maturation
- number
- transport in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lnx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- protein binding
- metal ion binding
- PDZ domain binding