Cenpc1 Gene Summary [Mouse]
This gene encodes a centromeric protein component of a nucleosome-associated complex that plays a central role in kinetochore protein assembly, mitotic progression and chromosome segregation. The human ortholog encodes a protein with DNA-binding activity, that associates constitutively to kinetochores throughout the cell cycle, as part of a prekinetochore complex, together with centromeric protein-A and centromeric protein-B. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | Cenpc1 |
| Official Name | centromere protein C1 [Source:MGI Symbol;Acc:MGI:99700] |
| Ensembl ID | ENSMUSG00000029253 |
| Bio databases IDs | |
| Aliases | centromere protein C1 |
| Synonyms | CENPC1, centromere protein C, centromere protein C1, hcp-4, MIF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cenpc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- Kinetochore assembly subunit CENP-C N-terminal
- CENP-C motif
- Mis12 binding domain
- central domain
- protein binding
- RmlC-like cupin superfamily
- Centromere assembly component CENP-C middle DNMT3B-binding region
- identical protein binding
- DNA binding
- kinetochore binding domain
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- midbody
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear scaffolds
- kinetochores
- centromeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cenpc1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation
- chromosome segregation
- kinetochore assembly
- mitotic cell cycle
- attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- nuclear body
- condensed chromosome, centromeric region
- cytosol
- midbody
- kinetochore
- centromeric heterochromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein binding
- centromeric DNA binding