Prkra Gene Summary [Mouse]
Predicted to enable several functions, including RNA binding activity; protein homodimerization activity; and protein kinase activator activity. Acts upstream of or within several processes, including cellular response to oxidative stress; ear morphogenesis; and positive regulation of intrinsic apoptotic signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of RISC complex and RISC-loading complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including 4-cell stage embryo; central nervous system; olfactory epithelium; and retina. Human ortholog(s) of this gene implicated in dystonia 16. Orthologous to human PRKRA (protein activator of interferon induced protein kinase EIF2AK2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prkra |
| Official Name | protein kinase, interferon inducible double stranded RNA dependent activator [Source:MGI Symbol;Acc:MGI:1344375] |
| Ensembl ID | ENSMUSG00000002731 |
| Bio databases IDs | |
| Aliases | protein kinase, interferon inducible double stranded RNA dependent activator |
| Synonyms | AV120107, DKFZP564I0123, DYT16, HSD14, lear, PACT, PRK, protein activator of interferon induced protein kinase EIF2AK2, protein kinase, interferon inducible double stranded RNA dependent activator, RAX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prkra often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- protein kinase binding
- Double-stranded RNA binding motif
- double-stranded RNA binding motif (DSRM) superfamily
- double-stranded RNA binding
- protein homodimerization
- enzyme binding
- protein binding
- dsRNA-binding domain
- enzyme activator activity
- identical protein binding
- RNA binding
Pathways
Biological processes and signaling networks where the Prkra gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- multiple sclerosis
- metastasis
- systemic lupus erythematosus
- dystonia type 16
- lung adenocarcinoma formation
- organismal death
- autosomal recessive nonsyndromic mental retardation
- lung adenocarcinoma
- psoriasis
- hypoplasia
role in cell
- apoptosis
- expression in
- proliferation
- activation in
- migration
- number
- response by
- processing in
- sumoylation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prkra gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pre-miRNA processing
- production of miRNAs involved in gene silencing by miRNA
- negative regulation of cell proliferation
- outer ear morphogenesis
- middle ear morphogenesis
- response to virus
- skeletal system morphogenesis
- immune response
- cellular response to oxidative stress
- production of siRNA involved in RNA interference
- protein stabilization
- small RNA loading onto RISC
- positive regulation of intrinsic apoptotic signaling pathway
- regulation of production of small RNA involved in gene silencing by RNA
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- cytoplasm
- membrane
- RISC-loading complex
- cytosol
- RNA-induced silencing complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- RNA binding
- protein binding
- protein homodimerization activity
- double-stranded RNA binding
- protein kinase activator activity
- siRNA binding
- enzyme activator activity
- pre-miRNA binding
- enzyme binding