Rps6 Gene Summary [Mouse]
A structural constituent of ribosome. Involved in glucose homeostasis. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; T cell activation; and ribosome biogenesis. Located in dendrite; perinuclear region of cytoplasm; and ribosome. Part of cytosolic small ribosomal subunit. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and hemolymphoid system gland. Orthologous to human RPS6 (ribosomal protein S6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps6 |
| Official Name | ribosomal protein S6 [Source:MGI Symbol;Acc:MGI:98159] |
| Ensembl ID | ENSMUSG00000028495 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 |
| Synonyms | eS6, LOC100911372, pp33, Q9BZU1, RIBOSOMAL protein S6, S6, S6R, S6RP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- protein kinase binding
- mRNA binding
- protein binding
- Ribosomal protein S6e
Pathways
Biological processes and signaling networks where the Rps6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- non-small cell lung cancer
- acinar-cell carcinoma
- insulin-dependent diabetes mellitus
- non-small cell lung carcinoma
- thrombocytosis
- hypoplasia
- pancreatic neoplasia
- myelodysplastic syndrome
- retinitis pigmentosa
role in cell
- maturation
- expression in
- phosphorylation in
- proliferation
- apoptosis
- synthesis in
- quantity
- formation
- downregulation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- ribosomal fraction
- apical ectoplasmic specialization
- pre-ribosome
- cytoplasmic ribonucleoprotein granule
- presynaptic regions
- perinuclear region
- ribosome
- Nucleus
- Endoplasmic Reticulum
- microtubules
- polysomes
- cytosol
- nucleoplasm
- nucleoli
- nuclear envelope
- dendrite initial segments
- synapse
- perikaryon
- dendrites
- inhibitory synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oogenesis stage
- T cell differentiation in thymus
- cytoplasmic translation
- positive regulation of cell proliferation
- TOR signaling cascade
- erythrocyte development
- rRNA processing
- placenta development
- gastrulation
- translation
- activation-induced cell death of T cells
- negative regulation of apoptotic process
- G1/S transition of mitotic cell cycle
- positive regulation of apoptotic process
- glucose homeostasis
- ribosomal small subunit biogenesis
- T cell proliferation involved in immune response
Cellular Component
Where in the cell the gene product is active
- small-subunit processome
- cytosolic ribosome
- cytosolic small ribosomal subunit
- endoplasmic reticulum
- nucleolus
- nucleoplasm
- nucleus
- dendrite
- perinuclear region of cytoplasm
- cytoplasm
- cell body
- membrane
- cytosol
- small ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA binding
- protein binding
- structural constituent of ribosome