Slc6a12 Gene Summary [Mouse]

Enables gamma-aminobutyric acid:sodium:chloride symporter activity. Involved in gamma-aminobutyric acid transport and glycine betaine transport. Located in basolateral plasma membrane. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and liver and biliary system. Orthologous to human SLC6A12 (solute carrier family 6 member 12). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Slc6a12
Official Name
solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12 [Source:MGI Symbol;Acc:MGI:95628]
Ensembl ID
ENSMUSG00000030109
Bio databases IDs NCBI: 14411 Ensembl: ENSMUSG00000030109
Aliases solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Synonyms BGT-1, Gabt2, GAT-2, solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc6a12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Sodium:neurotransmitter symporter family
  • monocarboxylic acid transporter
  • Solute carrier families 5 and 6-like; solute binding domain
  • GABA:sodium symporter
  • transporter

Pathways

Biological processes and signaling networks where the Slc6a12 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
regulated by
regulates
  • GABA
role in cell
  • differentiation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane
  • basolateral membrane

Gene-Specific Assays for Results You Can Trust

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