Prdm1 Gene Summary [Mouse]
Enables histone methyltransferase binding activity; promoter-specific chromatin binding activity; and transcription cis-regulatory region binding activity. Involved in gene expression; peptidyl-arginine methylation; and regulation of lymphocyte differentiation. Acts upstream of or within several processes, including circulatory system development; eye morphogenesis; and regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; retina; and skin. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human PRDM1 (PR/SET domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm1 |
| Official Name | PR domain containing 1, with ZNF domain [Source:MGI Symbol;Acc:MGI:99655] |
| Ensembl ID | ENSMUSG00000038151 |
| Bio databases IDs | |
| Aliases | PR domain containing 1, with ZNF domain |
| Synonyms | b2b1765Clo, BLIMP-1, PRDI-BF1, PRDM, PR domain containing 1, with ZNF domain, PR/SET domain 1, ZNFPR1A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- DNA binding domain
- nucleic acid binding
- enzyme binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- proline rich domain
- acidic domain
- C2H2-type zinc finger
- zinc finger
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- transcription repression domain
- double-stranded DNA binding
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- zinc finger domain
- PR domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Prdm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- bleeding
- neutrophilia
- epithelial cancer
- experimental autoimmune encephalomyelitis
- cancer
- breast carcinoma
- plasma cell myeloma
- nummular eczema
- activated B-cell-like diffuse large B-cell lymphoma
role in cell
- number
- apoptosis
- expression in
- production in
- quantity
- degradation in
- cell death
- differentiation
- cellular infiltration by
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cell surface
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of extrathymic T cell differentiation
- retinal bipolar neuron differentiation
- heart valve development
- post-embryonic development
- maternal placenta development
- negative regulation of transcription from RNA polymerase II promoter
- morphogenesis of a branching structure
- regulation of natural killer cell differentiation
- kidney development
- trophoblast giant cell differentiation
- germ cell development
- ventricular septum development
- coronary vasculature development
- eye photoreceptor cell development
- adaptive immune response
- artery morphogenesis
- intestinal epithelial cell development
- regulation of cell proliferation
- regulation of transcription from RNA polymerase II promoter
- regulation of NK T cell differentiation
- negative regulation of gene expression
- aorta development
- innate immune response
- positive regulation of gene expression
- cell fate commitment
- gene expression
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- methyltransferase activity
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription