Rbbp6 Gene Summary [Mouse]
Predicted to enable protein kinase binding activity and ubiquitin protein ligase activity. Involved in ubiquitin-dependent protein catabolic process. Acts upstream of or within embryonic organ development; in utero embryonic development; and somite development. Predicted to be located in nuclear speck. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Predicted to colocalize with centrosome. Is expressed in lung; tongue; and upper jaw. Orthologous to human RBBP6 (RB binding protein 6, ubiquitin ligase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbbp6 |
| Official Name | retinoblastoma binding protein 6, ubiquitin ligase [Source:MGI Symbol;Acc:MGI:894835] |
| Ensembl ID | ENSMUSG00000030779 |
| Bio databases IDs | |
| Aliases | retinoblastoma binding protein 6, ubiquitin ligase |
| Synonyms | 4933422O15Rik, BB233631, C030034J04RIK, C77662, MY038, P2P-R, PACT, RB binding protein 6, ubiquitin ligase, RBQ-1, retinoblastoma binding protein 6, ubiquitin ligase, SNAMA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbbp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc knuckle
- protein kinase binding
- ubiquitin protein ligase activity
- enzyme
- protein binding
- Protein of unknown function, DUF612
- zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Modified RING finger domain
- Ring finger
- ubiquitin-protein transferase activity
- DWNN domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- growth failure
- senile lentigo
- diabetic retinopathy
- colon neoplasm
- colorectal neoplasia
- ductal breast carcinoma
- ductal breast cancer
role in cell
- apoptosis
- growth
- mitotic entry in
- 3' end processing in
- G2/M phase
- BI-2536 sensitivity
- checkpoint recovery in
- DNA damage response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- cytosol
- nuclear speckles
- rough endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbbp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- somite development
- in utero embryonic development
- DNA replication
- regulation of DNA replication
- embryonic organ development
- response to DNA damage stimulus
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- nuclear speck
- cytosol
- macromolecular complex
- chromosome
- nucleolus
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein kinase binding
- zinc ion binding
- protein binding
- RNA binding