Tob1 Gene Summary [Mouse]
Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in several structures, including 1st branchial arch; back skin; genitourinary system; limb; and sensory organ. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tob1 |
| Official Name | transducer of ErbB-2.1 [Source:MGI Symbol;Acc:MGI:1349721] |
| Ensembl ID | ENSMUSG00000037573 |
| Bio databases IDs | |
| Aliases | transducer of ErbB-2.1 |
| Synonyms | APRO5, APRO6, PIG49, TOB, TRANSDUCER of ERBB2, transducer of ErbB-2.1, transducer of ERBB2, 1, TROB, TROB1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tob1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- SMAD binding
- transcription regulator
- receptor tyrosine kinase binding
- transcription co-repressor
- PABP binding domain
- protein binding
- tob/btg1 family
Pathways
Biological processes and signaling networks where the Tob1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- tumorigenesis
- paroxysmal nocturnal hemoglobinuria
- experimental autoimmune encephalomyelitis
- peripheral T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- ankylosing spondylitis
role in cell
- growth
- proliferation
- migration
- expression in
- phosphorylation in
- number
- binding in
- invasion by
- quantity
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tob1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of BMP signaling pathway
- negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of transcription, DNA-dependent
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- negative regulation of cell proliferation
- regulation of gene expression
- regulation of SMAD protein import into nucleus
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
- negative regulation of translation
- negative regulation of osteoblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- transcription corepressor activity
- receptor tyrosine kinase binding