Acin1 Gene Summary [Mouse]
Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including apoptotic chromosome condensation; negative regulation of mRNA splicing, via spliceosome; and positive regulation of monocyte differentiation. Predicted to act upstream of or within apoptotic process. Located in nucleolus. Is expressed in several structures, including central nervous system; connective tissue; early conceptus; olfactory epithelium; and retina. Orthologous to human ACIN1 (apoptotic chromatin condensation inducer 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acin1 |
| Official Name | apoptotic chromatin condensation inducer 1 [Source:MGI Symbol;Acc:MGI:1891824] |
| Ensembl ID | ENSMUSG00000022185 |
| Bio databases IDs | |
| Aliases | apoptotic chromatin condensation inducer 1 |
| Synonyms | 2610036I19Rik, 2610510L13Rik, ACINU, ACINUS, ACINUS-1, acinusL, acinusS, ACN, apoptotic chromatin condensation inducer 1, Apoptotic Chromatin Condensation Inducer In The Nucleus, fSAP152, mKIAA0670 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Acin1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- SAP motif
- RNA recognition motif
- SAP domain
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Acin1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nonalcoholic fatty liver disease
- breast cancer
- idiopathic scoliosis
role in cell
- production in
- proliferation
- cell death
- apoptosis
- expression in
- binding in
- migration
- growth
- splicing by
- condensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Plasma Membrane
- cytosol
- spliceosomes
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Acin1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- erythrocyte differentiation
- apoptotic chromosome condensation
- mRNA processing
- positive regulation of monocyte differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- nucleic acid binding
- RNA binding
- protein binding
- enzyme binding