Ldhc Gene Summary [Mouse]
Enables L-lactate dehydrogenase activity. Acts upstream of or within ATP biosynthetic process; flagellated sperm motility; and monocarboxylic acid metabolic process. Located in cytoplasm and motile cilium. Is active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human LDHC (lactate dehydrogenase C). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ldhc |
| Official Name | lactate dehydrogenase C [Source:MGI Symbol;Acc:MGI:96764] |
| Ensembl ID | ENSMUSG00000030851 |
| Bio databases IDs | |
| Aliases | lactate dehydrogenase C |
| Synonyms | CT32, Lactate dehydrogenase 3, lactate dehydrogenase C, LDH3, LDHX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ldhc often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- L-lactate dehydrogenase
- lactate/malate dehydrogenase, NAD binding domain
- enzyme
- protein binding
- lactate/malate dehydrogenase, alpha/beta C-terminal domain
- lactate dehydrogenase
- malate dehydrogenase, NAD-dependent
Pathways
Biological processes and signaling networks where the Ldhc gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- asthenozoospermia
- sporadic amyotrophic lateral sclerosis
- Guillain-Barré syndrome
- placental cancer
regulates
- lactic acid
- adenosine triphosphate
- pyruvic acid
role in cell
- function
- motility
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- cilia
- cytosol
- cytoplasmic droplets
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ldhc gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- pyruvate catabolic process
- lactate oxidation
- sperm motility
- lactate biosynthetic process from pyruvate
- lactate metabolic process
- ATP biosynthetic process
- pyruvate metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- motile cilium
- extracellular vesicular exosome
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- L-lactate dehydrogenase activity