Yeats2 Gene Summary [Mouse]
Predicted to enable several functions, including TBP-class protein binding activity; histone binding activity; and transcription corepressor activity. Involved in regulation of cell cycle; regulation of cell division; and regulation of embryonic development. Located in mitotic spindle and nucleus. Part of ATAC complex. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 4. Orthologous to human YEATS2 (YEATS domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Yeats2 |
| Official Name | YEATS domain containing 2 [Source:MGI Symbol;Acc:MGI:2447762] |
| Ensembl ID | ENSMUSG00000041215 |
| Bio databases IDs | |
| Aliases | YEATS domain containing 2 |
| Synonyms | FAME4, mKIAA1197, RGD1566176, YEATS domain containing 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Yeats2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone-fold domain
- YEATS domain
- YEATS domain family, chromatin reader proteins
- histone binding
- transcription regulator
- transcription co-repressor
- protein binding activity, bridging
- protein binding
- YEATS family
- TATA-binding protein binding
- prokaryotic YEATS domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- prostate cancer
- prostatic carcinoma
- breast cancer
- familial adult myoclonic epilepsy type 4
- toxic epidermal necrolysis
regulates
- DNA promoter
- DNA endogenous promoter
- Tk
- RNA polymerase II
role in cell
- expression in
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Yeats2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- chromatin remodeling
- regulation of tubulin deacetylation
- regulation of embryonic development
- regulation of transcription, DNA-dependent
- regulation of cell cycle
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- NuA4 histone acetyltransferase complex
- mitotic spindle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- transcription corepressor activity
- TBP-class protein binding