Brs3 Gene Summary [Mouse]
Predicted to enable neuropeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in neuronal cell body. Predicted to be active in plasma membrane. Is expressed in lung; lung epithelium; lung mesenchyme; pons; and pons mantle layer. Orthologous to human BRS3 (bombesin receptor subtype 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Brs3 |
| Official Name | bombesin-like receptor 3 [Source:MGI Symbol;Acc:MGI:1100501] |
| Ensembl ID | ENSMUSG00000031130 |
| Bio databases IDs | |
| Aliases | bombesin-like receptor 3 |
| Synonyms | BB3, BB3R, BBR3, bombesin-like receptor 3, bombesin receptor subtype 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Brs3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- bombesin receptor
Pathways
Biological processes and signaling networks where the Brs3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- [D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin-(6-14)
- [D-Phe6, beta-Ala11, Phe13, Nle14] bombesin (6-14)
- [D-Tyr6,(R)-Apa11,3-Cl-Phe13,Nle14]bombesin(6-14)
- [D-Tyr6,(R)-Apa11,Phe13,Nle14]bombesin(6-14)
- [D-Tyr6,(R)-Apa11,4-Cl-Phe13,Nle14]Bn(6-14)
- [D-Tyr6,(R)-Apa11-2Cl,Phe13,Nle14] bombesin (6-14)
- Ac-Phe-Trp-Ala-His(tBzl)-Nip-Gly-Arg-NH2
- [D-Tyr6,(S)-Apa11-4Cl,Phe13,Nle14] bombesin (6-14)
- [D-Tyr6,beta-Dap11,Phe13,Nle14]bombesin(6-14)
- dY-bombesin
disease
- weight gain
- hypertension
- hyperphagia
- obesity
regulated by
- beta-estradiol
- dY-bombesin
- [D-Tyr6,(R)-Apa11,4-Cl-Phe13,Nle14]Bn(6-14)
role in cell
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Brs3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bombesin receptor signaling pathway
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- adult feeding behavior
- glucose metabolic process
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide receptor activity
- bombesin receptor activity