BRS3 Gene Summary [Human]
The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]
Details
| Type | Protein Coding |
| Official Symbol | BRS3 |
| Official Name | bombesin receptor subtype 3 [Source:HGNC Symbol;Acc:HGNC:1113] |
| Ensembl ID | ENSG00000102239 |
| Bio databases IDs | |
| Aliases | bombesin receptor subtype 3 |
| Synonyms | BB3, BB3R, BBR3, bombesin-like receptor 3, bombesin receptor subtype 3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
- bombesin receptor
Pathways
Biological processes and signaling networks where the BRS3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- [D-Tyr6,beta-Ala11,Phe13,Nle14]bombesin-(6-14)
- [D-Phe6, beta-Ala11, Phe13, Nle14] bombesin (6-14)
- [D-Tyr6,(R)-Apa11,3-Cl-Phe13,Nle14]bombesin(6-14)
- [D-Tyr6,(R)-Apa11,Phe13,Nle14]bombesin(6-14)
- [D-Tyr6,(R)-Apa11,4-Cl-Phe13,Nle14]Bn(6-14)
- [D-Tyr6,(R)-Apa11-2Cl,Phe13,Nle14] bombesin (6-14)
- Ac-Phe-Trp-Ala-His(tBzl)-Nip-Gly-Arg-NH2
- [D-Tyr6,(S)-Apa11-4Cl,Phe13,Nle14] bombesin (6-14)
- [D-Tyr6,beta-Dap11,Phe13,Nle14]bombesin(6-14)
- dY-bombesin
disease
- weight gain
- hypertension
- hyperphagia
- obesity
regulated by
- beta-estradiol
- dY-bombesin
- [D-Tyr6,(R)-Apa11,4-Cl-Phe13,Nle14]Bn(6-14)
role in cell
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bombesin receptor signaling pathway
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- adult feeding behavior
- glucose metabolic process
- regulation of blood pressure
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- neuropeptide receptor activity
- bombesin receptor activity