Arv1 Gene Summary [Mouse]
Acts upstream of or within bile acid metabolic process and regulation of cholesterol metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus and cortical endoplasmic reticulum. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 38. Orthologous to human ARV1 (ARV1 homolog, fatty acid homeostasis modulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Arv1 |
| Official Name | ARV1 homolog, fatty acid homeostasis modulator [Source:MGI Symbol;Acc:MGI:1916115] |
| Ensembl ID | ENSMUSG00000031982 |
| Bio databases IDs | |
| Aliases | ARV1 homolog, fatty acid homeostasis modulator |
| Synonyms | 1110067L22Rik, ARV1 homolog, fatty acid homeostasis modulator, DEE38, EIEE38, RGD1310264 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Arv1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- protein binding
- Arv1-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- hereditary disorder
- early infantile epileptic encephalopathy type 38
- seizures
phenotypes
- abnormal auditory brainstem response
- hyperactivity
- increased thigmotaxis
- abnormal bile salt homeostasis
- abnormal circulating lipid level
- abnormal enzyme/coenzyme level
- abnormal feces composition
- abnormal intestine physiology
- abnormal lipid metabolism
- abnormal liver physiology
- abnormal locomotor activation
- abnormal maternal nurturing
- decreased body fat mass
- decreased brown adipose tissue amount
- decreased circulating HDL cholesterol level
- decreased circulating cholesterol level
- decreased circulating lactate dehydrogenase level
- decreased circulating leptin level
- decreased circulating triglyceride level
- decreased epididymal fat pad weight
- decreased fasting circulating glucose level
- decreased inguinal fat pad weight
- decreased lean body mass
- decreased liver cholesterol level
- decreased liver free fatty acids level
- decreased liver triglyceride level
- decreased mesenteric fat pad weight
- decreased percent body fat/body weight
- decreased respiratory quotient
- decreased retroperitoneal fat pad weight
- decreased subcutaneous adipose tissue amount
- decreased survivor rate
- decreased susceptibility to diet-induced obesity
- decreased susceptibility to hepatic steatosis
- decreased unsaturated fatty acid level
- decreased white adipose tissue amount
- decreased white fat cell size
- female infertility
- hypoglycemia
- impaired coordination
- improved glucose tolerance
- increased basal metabolism
- increased bile salt level
- increased blood urea nitrogen level
- increased carbon dioxide production
- increased circulating HDL cholesterol level
- increased circulating adiponectin level
- increased circulating alkaline phosphatase level
- increased circulating cholesterol level
- increased circulating ghrelin level
- increased energy expenditure
- increased fatty acid oxidation
- increased food intake
- increased insulin sensitivity
- increased oxygen consumption
- increased saturated fatty acid level
- increased unsaturated fatty acid level
- moribund
- poor circulation
- premature death
- seizures
- slow postnatal weight gain
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Arv1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of plasma membrane sterol distribution
- regulation of intracellular cholesterol transport
- intracellular sterol transport
- cholesterol biosynthetic process
- cholesterol transport
- sterol metabolic process
- bile acid metabolic process
- sphingolipid metabolic process
- regulation of cholesterol metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi apparatus
- cortical endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding