Ippk Gene Summary [Mouse]
Predicted to enable inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity and molecular adaptor activity. Predicted to be involved in inositol phosphate biosynthetic process and positive regulation of transcription of nucleolar large rRNA by RNA polymerase I. Predicted to be located in nucleolus. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human IPPK (inositol-pentakisphosphate 2-kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ippk |
| Official Name | inositol 1,3,4,5,6-pentakisphosphate 2-kinase [Source:MGI Symbol;Acc:MGI:1922928] |
| Ensembl ID | ENSMUSG00000021385 |
| Bio databases IDs | |
| Aliases | inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
| Synonyms | 1810043M15Rik, bA476B13.1, C9orf12, inositol 1,3,4,5,6-pentakisphosphate 2-kinase, inositol-pentakisphosphate 2-kinase, InsP5-2K, INSP5 2-KINASE, INSP5K2, InsP6, IP5K, IPK1, RGD1311271, rIpk1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ippk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- inositol-pentakisphosphate 2-kinase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulated by
- SL 327
- levodopa
role in cell
- apoptosis
- organismal death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ippk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inositol phosphate metabolic process
- inositol phosphate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- inositol pentakisphosphate 2-kinase activity
- protein binding
- binding, bridging