Grpr Gene Summary [Mouse]
This gene encodes a multipass membrane protein that functions as a receptor for gastrin releasing peptide. Signalling through this receptor is important in a variety of physiological processes, including responses to itching, satiety, and fear. [provided by RefSeq, May 2015]
Details
| Type | Protein Coding |
| Official Symbol | Grpr |
| Official Name | gastrin releasing peptide receptor [Source:MGI Symbol;Acc:MGI:95836] |
| Ensembl ID | ENSMUSG00000031364 |
| Bio databases IDs | |
| Aliases | gastrin releasing peptide receptor |
| Synonyms | BB2, BB2R, Bb2 Receptor, BR, BRS1, BRS2, gastrin releasing peptide receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grpr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- extracellular domain
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- DRY motif
- neuropeptide receptor
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- bombesin receptor
- neuropeptide binding
- transmembrane domain
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
Pathways
Biological processes and signaling networks where the Grpr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- Huntington disease
- pruritus
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- leiomyoma
- leiomyomatosis
- endometrial carcinoma
- epithelial endometrial cancer
role in cell
- expression in
- activation in
- proliferation
- action potential
- recruitment in
- mobilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grpr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- social behavior
- response to external biotic stimulus
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- positive regulation of behavioral fear response
- phospholipase C-activating G-protein coupled receptor signaling pathway
- regulation of cell proliferation
- learning or memory
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled peptide receptor activity
- neuropeptide binding
- neuropeptide receptor activity