Btg4 Gene Summary [Mouse]
Enables mRNA 3'-UTR binding activity. Acts upstream of or within maternal-to-zygotic transition of gene expression and negative regulation of mitotic cell cycle. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; early embryo; gonad; nasal cavity epithelium; and retina. Orthologous to human BTG4 (BTG anti-proliferation factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btg4 |
| Official Name | BTG anti-proliferation factor 4 [Source:MGI Symbol;Acc:MGI:1860140] |
| Ensembl ID | ENSMUSG00000032056 |
| Bio databases IDs | |
| Aliases | BTG anti-proliferation factor 4 |
| Synonyms | APRO3, BTG anti-proliferation factor 4, LOC101928620, OOMD8, OZEMA8, PC3B, SCIR-27 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BTG family
- mRNA 3' UTR binding
- protein binding
- tob/btg1 family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron differentiation
- negative regulation of cell proliferation
- negative regulation of mitotic cell cycle
- regulation of cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding