Cnot6l Gene Summary [Mouse]
Enables poly(A)-specific ribonuclease activity. Acts upstream of or within nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay and positive regulation of cell population proliferation. Located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and musculature. Orthologous to human CNOT6L (CCR4-NOT transcription complex subunit 6 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cnot6l |
| Official Name | CCR4-NOT transcription complex, subunit 6-like [Source:MGI Symbol;Acc:MGI:2443154] |
| Ensembl ID | ENSMUSG00000034724 |
| Bio databases IDs | |
| Aliases | CCR4-NOT transcription complex, subunit 6-like |
| Synonyms | 4932442K20RIK, CCR4b, CCR4-NOT transcription complex subunit 6 like, CCR4-NOT transcription complex, subunit 6-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cnot6l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Leucine-rich repeats, outliers
- Leucine-rich repeats, typical (most populated) subfamily
- poly(A)-specific ribonuclease
- Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily
- Endonuclease/Exonuclease/phosphatase family
- Leucine rich repeat
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric epithelial cancer
- gastric adenocarcinoma
- metabolic disorder
- gastric cancer
role in cell
- expression in
- proliferation
- formation
- accumulation in
- tumorigenicity
- differentiation
- growth
- formation in
- assembly
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cnot6l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- positive regulation of cytoplasmic mRNA processing body assembly
- positive regulation of cell proliferation
- gene silencing by RNA
- mRNA processing
- nuclear-transcribed mRNA poly(A) tail shortening
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- CCR4-NOT complex
Molecular Function
What the gene product does at the molecular level
- poly(A)-specific ribonuclease activity
- protein binding
- metal ion binding