Man2c1 Gene Summary [Mouse]
Enables alpha-mannosidase activity. Involved in oligosaccharide catabolic process. Is active in cytosol. Human ortholog(s) of this gene implicated in congenital disorder of deglycosylation 2. Orthologous to human MAN2C1 (mannosidase alpha class 2C member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Man2c1 |
| Official Name | mannosidase, alpha, class 2C, member 1 [Source:MGI Symbol;Acc:MGI:1920994] |
| Ensembl ID | ENSMUSG00000032295 |
| Bio databases IDs | |
| Aliases | mannosidase, alpha, class 2C, member 1 |
| Synonyms | 1110025H24Rik, AMAN, CDDG2, MAN6A8, MANA, MANA1, mannosidase alpha class 2C member 1, mannosidase, alpha, class 2C, member 1, mannosidase α class 2C member 1, mannosidase, α, class 2C, member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Man2c1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha mannosidase middle domain
- Glycosyl hydrolases family 38 N-terminal domain
- alpha-mannosidase
- GH38-57_N_LamB_YdjC_SF
- Alpha mannosidase, middle domain
- Glycosyl hydrolases family 38 C-terminal domain
- Glycosyl hydrolases family 38 C-terminal beta sandwich domain
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of deglycosylation type 2
- edema
- hepatic steatosis
- otosclerosis
- fibrosis
regulated by
- TCL1A
regulates
- AKT
- glycogen
- mannose8-N-acetylglucosamine
- Man9-GlcNAc
- DDIT3
- oligosaccharide
role in cell
- expression in
- apoptosis
- formation
- formation in
- swelling
- degeneration
- function
- abnormal morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Man2c1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mannose metabolic process
- oligosaccharide catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- alpha-mannosidase activity
- metal ion binding
- carbohydrate binding