MAN2C1 Gene Summary [Human]
Predicted to enable alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | MAN2C1 |
| Official Name | mannosidase alpha class 2C member 1 [Source:HGNC Symbol;Acc:HGNC:6827] |
| Ensembl ID | ENSG00000140400 |
| Bio databases IDs | |
| Aliases | mannosidase alpha class 2C member 1 |
| Synonyms | 1110025H24Rik, AMAN, CDDG2, MAN6A8, MANA, MANA1, mannosidase alpha class 2C member 1, mannosidase, alpha, class 2C, member 1, mannosidase α class 2C member 1, mannosidase, α, class 2C, member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAN2C1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha mannosidase middle domain
- Glycosyl hydrolases family 38 N-terminal domain
- alpha-mannosidase
- GH38-57_N_LamB_YdjC_SF
- Alpha mannosidase, middle domain
- Glycosyl hydrolases family 38 C-terminal domain
- Glycosyl hydrolases family 38 C-terminal beta sandwich domain
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- congenital disorder of deglycosylation type 2
- edema
- hepatic steatosis
- otosclerosis
- fibrosis
regulated by
role in cell
- expression in
- apoptosis
- formation
- formation in
- swelling
- degeneration
- function
- abnormal morphology
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAN2C1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mannose metabolic process
- oligosaccharide catabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- alpha-mannosidase activity
- metal ion binding
- carbohydrate binding