Rps6ka1 Gene Summary [Mouse]
Enables DNA-binding transcription factor binding activity and kinase activity. Involved in hepatocyte proliferation. Located in spindle. Is active in synapse. Is expressed in central nervous system; early conceptus; lumbar dorsal root ganglion; oocyte; and retina. Human ortholog(s) of this gene implicated in alcohol-related birth defects. Orthologous to human RPS6KA1 (ribosomal protein S6 kinase A1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rps6ka1 |
| Official Name | ribosomal protein S6 kinase polypeptide 1 [Source:MGI Symbol;Acc:MGI:104558] |
| Ensembl ID | ENSMUSG00000003644 |
| Bio databases IDs | |
| Aliases | ribosomal protein S6 kinase polypeptide 1 |
| Synonyms | HU-1, KS6A1, MAPKAPK1, MAPKAPK1A, MAPKAP kinase 1, MAPKAP Kinase 1 Alpha, MAPKAP Kinase 1 α, p90Rsk, p90-RSK 1, p90S6K, RIBOSOMAL protein S6 KINASE A, ribosomal protein S6 kinase A1, ribosomal protein S6 kinase polypeptide 1, RSK, RSK1, S6K-alpha-1, S6K-α-1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps6ka1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- ERK-binding site
- protein kinase
- protein threonine/tyrosine kinase
- kinase interacting domain
- Protein tyrosine and serine/threonine kinase
- regulatory linker region
- caspase inhibitor activity
- transcription factor binding
- linker domain
- PIF binding pocket
- protein binding
- Protein kinase domain
- C-terminal lobe/kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- N-terminal kinase domain
- ribosomal protein S6 kinase
- PDZ binding motif
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the Rps6ka1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- 14-3-3-mediated Signaling
- Adipogenesis pathway
- Antiproliferative Role of TOB in T Cell Signaling
- Apoptosis Signaling
- Cardiac Hypertrophy Signaling
- CNTF Signaling
- CREB Signaling in Neurons
- ERK/MAPK Signaling
- ERK5 Signaling
- FLT3 Signaling in Hematopoietic Progenitor Cells
- G-Protein Coupled Receptor Signaling
- Growth Hormone Signaling
- IL-4 Signaling
- Melanocyte Development and Pigmentation Signaling
- mTOR Signaling
- Neurotrophin/TRK Signaling
- NGF Signaling
- p38 MAPK Signaling
- Role of IL-17A in Arthritis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
- Synaptic Long Term Potentiation
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- adenoma formation
- epithelial cancer
- liver cancer
- von Hippel-Lindau syndrome
- cystadenoma
- non-insulin-dependent diabetes mellitus
- hepatitis B virus-related hepatocellular carcinoma
- androgenic alopecia
- colon cancer
- nonalcoholic steatohepatitis
role in cell
- cell death
- phosphorylation in
- production in
- growth
- apoptosis
- cell viability
- invasion by
- proliferation
- number
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- spindle apparatus
- Nucleus
- Plasma Membrane
- cytosol
- nucleoplasm
- nucleoli
- nuclear rim
- nuclear speckles
- synapse
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps6ka1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of hepatic stellate cell activation
- signal transduction
- synaptic transmission
- positive regulation of cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- regulation of translation in response to stress
- positive regulation of cell growth
- positive regulation of transcription, DNA-dependent
- hepatocyte proliferation
- negative regulation of apoptotic process
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- negative regulation of TOR signaling cascade
- peptidyl-serine phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- synapse
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribosomal protein S6 kinase activity
- magnesium ion binding
- ATP binding
- protein serine/threonine/tyrosine kinase activity
- protein binding
- protein serine/threonine kinase activity
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process