Plekhs1 Gene Summary [Mouse]
Orthologous to human PLEKHS1 (pleckstrin homology domain containing S1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhs1 |
| Official Name | pleckstrin homology domain containing, family S member 1 [Source:MGI Symbol;Acc:MGI:2443041] |
| Ensembl ID | ENSMUSG00000035818 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family S member 1 |
| Synonyms | 9930023K05Rik, C10orf81, HEL185, pleckstrin homology domain containing, family S member 1, pleckstrin homology domain containing S1, RGD1559884 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhs1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PH domain
- protein binding
- Pleckstrin homology-like domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- acute lymphoblastic leukemia
- open-angle glaucoma
- breast carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- thyroid cancer
- bladder cancer
regulated by
- PTEN
- progesterone
- pictilisib
regulates
- AKT
- phosphatidylinositol-3,4,5-triphosphate
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown