Hspa2 Gene Summary [Mouse]
Enables glycolipid binding activity. Involved in positive regulation of ATPase-coupled calcium transmembrane transporter activity and spermatogenesis. Acts upstream of or within several processes, including male meiosis I; positive regulation of G2/M transition of mitotic cell cycle; and synaptonemal complex disassembly. Located in cell surface; meiotic spindle; and nucleus. Part of CatSper complex. Is expressed in several structures, including 2-cell stage embryo; alimentary system; ganglia; medulla oblongata basal plate; and submandibular gland primordium. Orthologous to human HSPA2 (heat shock protein family A (Hsp70) member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hspa2 |
| Official Name | heat shock protein 2 [Source:MGI Symbol;Acc:MGI:96243] |
| Ensembl ID | ENSMUSG00000059970 |
| Bio databases IDs | |
| Aliases | heat shock protein 2 |
| Synonyms | heat shock protein 2, heat shock protein family A (Hsp70) member 2, HSP70-2, HSP70.2, HSP70-3, HSP70A2, HSPT70, Hst70 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hspa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fe-S protein assembly chaperone HscA
- lipid binding
- binding protein
- MreB/Mbl protein
- tau protein binding
- chaperone protein DnaK
- enzyme binding
- protein domain specific binding
- protein binding
- chaperone binding
- Hsp70 protein
- ASKHA_ATPase-like
Pathways
Biological processes and signaling networks where the Hspa2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- glioblastoma
- androgenic alopecia
- aspermatogenesis
- glioblastoma cancer
role in cell
- differentiation
- apoptosis
- polyubiquitination in
- assembly
- meiosis
- development
- alternative splicing in
- disassembly
- presence
- meiosis I
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- cell surface
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
- synaptosomes
- meiotic spindles
- synaptonemal complexes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hspa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- male meiosis
- spermatogenesis
- male meiosis I
- chaperone mediated protein folding requiring cofactor
- protein refolding
- negative regulation of inclusion body assembly
- response to unfolded protein
- response to cold
- response to heat
- synaptonemal complex disassembly
- positive regulation of protein phosphorylation
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- plasma membrane
- synaptonemal complex
- male germ cell nucleus
- cell surface
- nucleus
- extracellular vesicular exosome
- cytoplasm
- membrane
- blood microparticle
- cytosol
- meiotic spindle
- CatSper complex
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- heat shock protein binding
- ATP binding
- protein binding involved in protein folding
- glycolipid binding
- protein binding
- tau protein binding
- chaperone binding
- unfolded protein binding
- enzyme binding