Ern1 Gene Summary [Mouse]
Enables RNA endonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of macromolecule metabolic process; and protein autophosphorylation. Acts upstream of or within endoplasmic reticulum unfolded protein response and negative regulation of intrinsic apoptotic signaling pathway. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; hemolymphoid system gland; long bone; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ern1 |
| Official Name | endoplasmic reticulum (ER) to nucleus signalling 1 [Source:MGI Symbol;Acc:MGI:1930134] |
| Ensembl ID | ENSMUSG00000020715 |
| Bio databases IDs | |
| Aliases | endoplasmic reticulum (ER) to nucleus signalling 1 |
| Synonyms | 9030414B18Rik, C85377, endoplasmic reticulum to nucleus signaling 1, endoplasmic reticulum to nucleus signalling 1, FLJ30999, hIRE1p, Inositol-requiring 1, IRE1, IRE1a, IRE1 alpha, IRE1P, IRE1 α, RGD1559716 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ern1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PQQ-like domain
- protein serine/threonine kinase
- Hsp70 protein binding
- RNAse-L-like domain
- ADP binding
- ATP binding
- heat shock protein binding
- enzyme
- Protein kinase domain
- identical protein binding
- effector domain
- activation loop
- endonuclease
- cytoplasmic domain
- nuclease domain
- RNase_Ire1_like
- Tyrosine kinase, catalytic domain
- RNase domain
- Protein kinase (unclassified specificity)
- PQQ-dependent dehydrogenases and related proteins
- Protein tyrosine and serine/threonine kinase
- platelet-derived growth factor receptor binding
- catalytic loop
- PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
- enzyme binding
- beta-propeller repeat
- protein binding
- magnesium ion binding
- endoplasmic reticulum lumenal domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- lumenal domain
- transmembrane domain
- protein homodimerization
- endoribonuclease
- luminal/IRE1-like
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Ern1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- knee osteoarthritis
- neoplasia
- collagen-induced arthritis
- non-insulin-dependent diabetes mellitus
- atherosclerosis
- Alzheimer disease
- hepatic steatosis
- weight loss
- albuminuria
- drug-induced liver disease
role in cell
- apoptosis
- expression in
- transactivation in
- transcription in
- phosphorylation in
- synthesis in
- proliferation
- differentiation
- cell death
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- Mitochondria
- ER-to-Golgi intermediate compartment
- endoplasmic reticulum membrane
- inner nuclear membrane
- nuclear rim
- smooth endoplasmatic reticulum
- rough endoplasmatic reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ern1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- positive regulation of RNA splicing
- protein autophosphorylation
- positive regulation of endoplasmic reticulum unfolded protein response
- protein phosphorylation
- mRNA catabolic process
- cellular response to glucose stimulus
- mRNA splicing, via endonucleolytic cleavage and ligation
- endothelial cell proliferation
- regulation of macroautophagy
- cellular response to unfolded protein
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- cellular response to vascular endothelial growth factor stimulus
- cellular response to hydrogen peroxide
- response to endoplasmic reticulum stress
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear inner membrane
- cytoplasm
- mitochondrion
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- platelet-derived growth factor receptor binding
- unfolded protein binding
- ADP binding
- protein serine/threonine kinase activity
- endoribonuclease activity
- magnesium ion binding
- ATP binding
- protein binding
- Hsp90 protein binding
- enzyme binding
- Hsp70 protein binding