Akp3

Predicted to enable alkaline phosphatase activity; metal ion binding activity; and protease binding activity. Acts upstream of or within neural tube development; neurogenesis; and post-anal tail morphogenesis. Located in brush border. Is expressed in duodenum; intestine; and jejunum. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to several human genes including ALPG (alkaline phosphatase, germ cell) and ALPI (alkaline phosphatase, intestinal). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Akp3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.