Lrfn3 Gene Summary [Mouse]

Predicted to be involved in regulation of presynapse assembly; regulation of synaptic membrane adhesion; and synaptic membrane adhesion. Located in cell surface. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human LRFN3 (leucine rich repeat and fibronectin type III domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Lrfn3
Official Name
leucine rich repeat and fibronectin type III domain containing 3 [Source:MGI Symbol;Acc:MGI:2442512]
Ensembl ID
ENSMUSG00000036957
Bio databases IDs NCBI: 233067 Ensembl: ENSMUSG00000036957
Aliases leucine rich repeat and fibronectin type III domain containing 3
Synonyms A530045B06RIK, FIGLER1, leucine rich repeat and fibronectin type III domain containing 3, SALM4
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lrfn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein phosphatase 1 regulatory subunit 42
  • FN3
  • immunoglobulin domain
  • Immunoglobulin like
  • Immunoglobulin I-set domain
  • Leucine rich repeat
  • Fibronectin type 3 domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
  • adhesion
  • assembly

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • cell surface
  • cellular membrane
  • presynaptic membrane
  • synaptic membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Lrfn3 gene, providing context for its role in the cell.

Cellular Component

Where in the cell the gene product is active
  • dendrite
  • presynaptic active zone membrane
  • plasma membrane
  • axon
  • cell surface

Gene-Specific Assays for Results You Can Trust

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