C1qb Gene Summary [Mouse]
Enables identical protein binding activity. Involved in synapse pruning. Acts upstream of or within inner ear development. Located in postsynapse. Is active in glutamatergic synapse. Is extrinsic component of postsynaptic membrane and extrinsic component of presynaptic membrane. Is expressed in several structures, including brain; genitourinary system; gut; immune system; and integumental system. Orthologous to human C1QB (complement C1q B chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C1qb |
| Official Name | complement component 1, q subcomponent, beta polypeptide [Source:MGI Symbol;Acc:MGI:88224] |
| Ensembl ID | ENSMUSG00000036905 |
| Bio databases IDs | |
| Aliases | complement component 1, q subcomponent, beta polypeptide |
| Synonyms | Adia, C1q Beta-Chain, C1QD2, C1q β-Chain, complement C1q B chain, complement component 1, q subcomponent, beta polypeptide, complement component 1, q subcomponent, β polypeptide |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C1qb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Collagen triple helix repeat (20 copies)
- protein binding
- identical protein binding
- globular head domain
- C1q domain
Pathways
Biological processes and signaling networks where the C1qb gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- septic shock
- sepsis
- complement component C1q deficiency type 2
- tuberculosis
- colorectal cancer
- lupus erythematosus
- complement component C1q deficiency
- diabetic nephropathy
- laser induced choroidal neovascularization
regulates
- S
- Complement component 1
role in cell
- pruning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- postsynaptic region
- Plasma Membrane
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse C1qb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- complement activation
- innate immune response
- complement activation, classical pathway
Cellular Component
Where in the cell the gene product is active
- complement component C1 complex
- collagen
- blood microparticle
- synapse
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding