Tmprss3 Gene Summary [Mouse]
Predicted to enable sodium channel regulator activity. Involved in sensory perception of sound. Located in endoplasmic reticulum and neuronal cell body. Is expressed in several structures, including alimentary system; genitourinary system; heart; inner ear; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 8 and sensorineural hearing loss. Orthologous to human TMPRSS3 (transmembrane serine protease 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmprss3 |
| Official Name | transmembrane protease, serine 3 [Source:MGI Symbol;Acc:MGI:2155445] |
| Ensembl ID | ENSMUSG00000024034 |
| Bio databases IDs | |
| Aliases | transmembrane protease, serine 3 |
| Synonyms | DFNB10, DFNB8, ECHOS1, TADG12, transmembrane protease, serine 3, transmembrane serine protease 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmprss3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Scavenger receptor cysteine-rich domain
- Trypsin-like serine protease
- Tryp_SPc
- peptidase
- Domain of unknown function (DUF1986)
- sodium channel regulator
- protease domain
- serine endopeptidase
- trypsin
- N-linked glycosylation site
- cytoplasmic domain
- transmembrane domain
- LDLa
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 8
- familial nonsyndromic hearing impairment
- hereditary disorder
- age-related hearing loss
- autosomal recessive deafness
- autosomal recessive nonsyndromic hearing loss
- sensorineural hearing loss
- ear malformation
- diabetic nephropathy
- hearing loss
regulates
- Na+
role in cell
- aggregation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmprss3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- proteolysis
- cellular sodium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- neuronal cell body
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- serine-type endopeptidase activity