Trim58 Gene Summary [Mouse]
Enables dynein heavy chain binding activity; dynein intermediate chain binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of erythrocyte enucleation; protein ubiquitination; and regulation of nuclear migration along microtubule. Predicted to be active in cytoplasm. Orthologous to human TRIM58 (tripartite motif containing 58). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Trim58 |
| Official Name | tripartite motif-containing 58 [Source:MGI Symbol;Acc:MGI:2684862] |
| Ensembl ID | ENSMUSG00000037124 |
| Bio databases IDs | |
| Aliases | tripartite motif-containing 58 |
| Synonyms | BIA2, Gm16, Gm1783, RGD1566174, tripartite motif-containing 58 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Trim58 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil (CC) domain of Drosophila brain tumor (brat) and similar proteins
- B-Box C-terminal domain
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- enzyme
- Ring finger domain
- associated with SPRY domains
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- dynein intermediate chain binding
- B-box zinc finger
- dynein heavy chain binding
- Apolipoprotein A1/A4/E domain
- SPRY-associated domain
- Domain of unknown function (DUF4200)
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- colon adenocarcinoma
- colon epithelial cancer
- colorectal cancer
- non-small cell lung cancer
- ulcerative colitis
- myeloproliferative disorder
- colitis
- infection by HIV-1
role in cell
- expression in
- activation in
- invasion by
- degradation in
- migration
- cell viability
- G1 phase
- ubiquitination in
- innate immune response in
- enucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Trim58 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- regulation of viral entry into host cell
- regulation of protein localization
- innate immune response
- protein polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- protein autoubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- protein homodimerization activity
- dynein heavy chain binding
- dynein intermediate chain binding