Mecom Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and histone H3K9 methyltransferase activity. Involved in hematopoietic stem cell proliferation; heterochromatin organization; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including embryonic limb morphogenesis; positive regulation of brown fat cell differentiation; and ureter morphogenesis. Located in nucleus. Is expressed in several structures, including brain; embryo mesenchyme; genitourinary system; respiratory system; and sensory organ. Used to study otitis media. Human ortholog(s) of this gene implicated in myeloid neoplasm. Orthologous to human MECOM (MDS1 and EVI1 complex locus). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mecom |
| Official Name | MDS1 and EVI1 complex locus [Source:MGI Symbol;Acc:MGI:95457] |
| Ensembl ID | ENSMUSG00000027684 |
| Bio databases IDs | |
| Aliases | MDS1 and EVI1 complex locus |
| Synonyms | AML1-EVI-1, D630039M04Rik, EVI1, Evi-1 locus zinc finger, Jbo, KMT8E, LOC103691544, Mds, MDS1, MDS1 and EVI1 complex locus, MDS1-EVI1, PRDM3, RUSAT2, Znfpr1b1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mecom often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- CtBP binding domain
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- DNA binding domain
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- histone lysine N-methyltransferase activity (H3-K9 specific)
- zinc finger
- transcription repression domain
- histone methyltransferase
- double-stranded DNA binding
- Zinc-finger double domain
- SET domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- protein homodimerization
- zinc finger domain
- PR domain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Mecom gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- prostate cancer
- irritable bowel syndrome
- neoplastic cell transformation
- major depression
- cardiovascular disorder
- gastroesophageal reflux
- epithelial cancer
- myeloproliferative disorder
- lung squamous cell carcinoma
phenotypes
- abnormal locomotor activation
- abnormal startle reflex
- decreased erythrocyte cell number
- decreased hematocrit
- decreased hemoglobin content
- decreased prepulse inhibition
- increased blood urea nitrogen level
- increased circulating amylase level
- increased lean body mass
- increased startle reflex
- increased total body fat amount
- limb grasping
- preweaning lethality complete penetrance
- abnormal amnion morphology
- abnormal bone marrow cell morphology/development
- abnormal common myeloid progenitor cell morphology
- abnormal cranial ganglia morphology
- abnormal craniofacial morphology
- abnormal diencephalon morphology
- abnormal fetal liver hematopoietic progenitor cell morphology
- abnormal forebrain morphology
- abnormal heart looping
- abnormal heart morphology
- abnormal hematopoietic precursor cell number
- abnormal hematopoietic stem cell morphology
- abnormal hematopoietic stem cell physiology
- abnormal immune system organ morphology
- abnormal limb development
- abnormal liver bud morphology
- abnormal mesonephros morphology
- abnormal miscarriage rate
- abnormal myotome development
- abnormal neutrophil differentiation
- abnormal pharyngeal arch morphology
- abnormal pinna reflex
- abnormal platelet morphology
- abnormal spinal nerve morphology
- abnormal superior glossopharyngeal ganglion morphology
- abnormal superior vagus ganglion morphology
- abnormal tympanic membrane morphology
- abnormal vitelline vasculature morphology
- absent hindlimb buds
- absent myotome
- absent paraxial mesoderm
- absent sclerotome
- brachydactyly
- deafness
- decreased B cell number
- decreased body size
- decreased body weight
- decreased embryo size
- decreased hematopoietic stem cell number
- decreased leukocyte cell number
- distended pericardium
- double outlet right ventricle
- edema
- embryonic lethality during organogenesis complete penetrance
- embryonic lethality during organogenesis incomplete penetrance
- enlarged pericardium
- hemorrhage
- impaired hearing
- incomplete somite formation
- increased leukocyte cell number
- increased sensitivity to xenobiotic induced morbidity/mortality
- increased susceptibility to otitis media
- interrupted aortic arch
- kyphosis
- lethality throughout fetal growth and development complete penetrance
- lethality complete penetrance
- malocclusion
- middle ear effusion
- middle ear polyps
- no abnormal phenotype detected
- overriding aortic valve
- pale placenta
- pale yolk sac
- perinatal lethality complete penetrance
- perinatal lethality incomplete penetrance
- persistent truncus arteriosis
- pharyngeal arch hypoplasia
- polydactyly
- postnatal growth retardation
- postnatal lethality complete penetrance
- pulmonary vascular congestion
- respiratory system inflammation
- skin edema
- small embryonic telencephalon
- small forelimb buds
- small trigeminal ganglion
- thrombocytopenia
- trabecula carnea hypoplasia
- tympanic membrane perforation
- ventricular septal defect
- weakness
- weight loss
role in cell
- number
- apoptosis
- quantity
- proliferation
- differentiation
- methylation in
- cell viability
- expression in
- growth
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mecom gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heterochromatin organization
- negative regulation of programmed cell death
- negative regulation of JNK cascade
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- apoptotic process
- hemopoietic stem cell proliferation
- regulation of cell cycle
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- histone deacetylase complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- histone methyltransferase activity (H3-K9 specific)
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription