Atp8a1 Gene Summary [Mouse]
Enables phosphatidylserine flippase activity. Involved in several processes, including learning; regulation of membrane lipid distribution; and synaptic vesicle endocytosis. Located in cytoplasmic vesicle and organelle membrane. Is active in glutamatergic synapse and synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human ATP8A1 (ATPase phospholipid transporting 8A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp8a1 |
| Official Name | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 [Source:MGI Symbol;Acc:MGI:1330848] |
| Ensembl ID | ENSMUSG00000037685 |
| Bio databases IDs | |
| Aliases | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 |
| Synonyms | AI481521, AI853962, Aminophospholipid Translocase, APLT, Atp3a2, ATPASEII, ATPase phospholipid transporting 8A1, ATPIA, ATPP2, AW743152, AW822227, B230107D19Rik, ClassI, Homo sapiens clone 23664 and 23905 mRNA sequence |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp8a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phospholipid transporter
- Mg2+-ATPase
- Phospholipid-translocating ATPase N-terminal
- protein binding
- ATPase, P-type (transporting), HAD superfamily, subfamily IC
- Phospholipid-translocating P-type ATPase C-terminal
- lipid transporter
- HAD-superfamily hydrolase, subfamily IIB
- aminophospholipid transporter
- phospholipid-translocating P-type ATPase, flippase
- potassium and/or sodium efflux P-type ATPase, fungal-type
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- schizophrenia
- lung adenocarcinoma
- lung adenocarcinoma formation
- insomnia
- Alzheimer disease
regulates
- phosphatidylserine
- ion
role in cell
- migration
- endocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- secretory granule membrane
- specific granule membrane
- cytosol
- lysosome membrane
- synaptic vesicles
- synapse
- cytoplasmic vesicles
- chromaffin vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp8a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phospholipid translocation
- ion transmembrane transport
- positive regulation of phospholipid translocation
- learning
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- chromaffin granule membrane
- endoplasmic reticulum
- Golgi apparatus
- organelle membrane
- plasma membrane
- trans-Golgi network
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- cytosol
- cytoplasmic vesicle
- synaptic vesicle membrane
- azurophil granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- magnesium ion binding
- ATP binding
- protein binding
- cation-transporting ATPase activity