Ttyh1 Gene Summary [Mouse]
This gene encodes a member of the Tweety family of membrane proteins. Members of this family contain five predicted transmembrane regions that are arranged in a characteristic pattern. In mouse, the protein is predominantly localized to the endoplasmic reticulum and displays calcium binding activity. Targeted knock out of this gene results in early embryonic lethality prior to the blastocyst stage. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Processed Transcript |
| Official Symbol | Ttyh1 |
| Official Name | tweety family member 1 [Source:MGI Symbol;Acc:MGI:1889007] |
| Ensembl ID | ENSMUSG00000030428 |
| Bio databases IDs | |
| Aliases | tweety family member 1 |
| Synonyms | 4930459B04Rik, 6330408P11Rik, mTTY1, tty, TTY1, tweety family member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ttyh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- volume-sensitive anion channel
- tweety N-terminal domain
- chloride channel
- calcium ion binding
- protein binding
- ion channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- idiopathic pulmonary fibrosis
- early onset hypertension
- adenoid cystic carcinoma
role in cell
- proliferation
- expression in
- number
- differentiation
- abnormal morphology
- assembly
- sphere formation
- morphogenesis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Golgi Apparatus
- Endoplasmic Reticulum
- synapse
- smooth endoplasmatic reticulum
- filopodia
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ttyh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ion transmembrane transport
- iron ion transport
- L-glutamate transport
- cell-substrate adhesion
- chloride transport
- filopodium assembly
- mitotic cell cycle
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- chloride channel complex
- filopodium membrane
- smooth endoplasmic reticulum membrane
- membrane
- filopodium tip
- synapse
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- intracellular calcium activated chloride channel activity
- iron ion transmembrane transporter activity
- calcium ion binding
- volume-sensitive chloride channel activity
- chloride channel activity
- volume-sensitive anion channel activity