Rilp Gene Summary [Mouse]
Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Predicted to be involved in several processes, including endosomal transport; intralumenal vesicle formation; and regulation of protein catabolic process. Located in mitochondrion. Part of protein-containing complex. Is expressed in brown fat; ileum; liver; male reproductive gland or organ; and metanephros. Orthologous to human RILP (Rab interacting lysosomal protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rilp |
| Official Name | Rab interacting lysosomal protein [Source:MGI Symbol;Acc:MGI:2144271] |
| Ensembl ID | ENSMUSG00000038195 |
| Bio databases IDs | |
| Aliases | Rab interacting lysosomal protein |
| Synonyms | AI835553, Gm857, PP10141, Rab interacting lysosomal protein |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rilp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rab7 binding domain
- enzyme binding
- Rab interacting lysosomal protein
- protein binding
- JNK_SAPK-associated protein-1
Pathways
Biological processes and signaling networks where the Rilp gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
regulated by
- CTNS
- levodopa
- lipopolysaccharide
- IgE
- OVALBUMIN
- indomethacin
- eptifibatide
- RAB7A
- Caco2 cells
- collagen-related peptide
role in cell
- formation
- formation in
- expression in
- aggregation
- morphology
- scattering
- accumulation in
- degradation in
- movement in
- loading in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- lysosome membrane
- late endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rilp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cilium morphogenesis
- early endosome to late endosome transport
- protein transport
- endosome transport via multivesicular body sorting pathway
- intralumenal vesicle formation
- positive regulation of protein catabolic process
- negative regulation of protein catabolic process
- endosome to lysosome transport
- regulation of multivesicular body size
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- cilium basal body
- cytoplasm
- late endosome
- phagocytic vesicle membrane
- macromolecular complex
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding
- dynein light intermediate chain binding
- protein dimerization activity