Phrf1 Gene Summary [Mouse]
Predicted to enable RNA polymerase binding activity and protein domain specific binding activity. Predicted to be involved in mRNA processing and transcription by RNA polymerase II. Is expressed in several structures, including central nervous system and retina. Orthologous to human PHRF1 (PHD and ring finger domains 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Phrf1 |
| Official Name | PHD and ring finger domains 1 [Source:MGI Symbol;Acc:MGI:2141847] |
| Ensembl ID | ENSMUSG00000038611 |
| Bio databases IDs | |
| Aliases | PHD and ring finger domains 1 |
| Synonyms | KIAA1542, LOC105376667, PHD and ring finger domains 1, PPP1R125, RNF221 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Phrf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- enzyme binding
- PHD finger superfamily
- protein domain specific binding
- Ring finger domain
- protein binding
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Phrf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- metal ion binding