PHRF1 Gene Summary [Human]
Predicted to enable RNA polymerase binding activity. Predicted to be involved in mRNA processing and transcription by RNA polymerase II. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PHRF1 |
| Official Name | PHD and ring finger domains 1 [Source:HGNC Symbol;Acc:HGNC:24351] |
| Ensembl ID | ENSG00000070047 |
| Bio databases IDs | |
| Aliases | PHD and ring finger domains 1, CTD binding SR like protein rA9, protein phosphatase 1, regulatory subunit 125 |
| Synonyms | KIAA1542, LOC105376667, PHD and ring finger domains 1, PPP1R125, RNF221 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHRF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PHD zinc finger
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- zinc finger of C3HC4-type, RING
- Ring finger
- enzyme binding
- PHD finger superfamily
- protein domain specific binding
- Ring finger domain
- protein binding
- RING-H2 zinc finger domain
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PHRF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- membrane
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- metal ion binding