Cntn5 Gene Summary [Mouse]
Predicted to enable cell-cell adhesion mediator activity. Involved in presynapse assembly. Acts upstream of or within sensory perception of sound. Is active in GABA-ergic synapse and presynaptic membrane. Is expressed in central nervous system. Orthologous to human CNTN5 (contactin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cntn5 |
| Official Name | contactin 5 [Source:MGI Symbol;Acc:MGI:3042287] |
| Ensembl ID | ENSMUSG00000039488 |
| Bio databases IDs | |
| Aliases | contactin 5 |
| Synonyms | 6720426O10Rik, A830025P08RIK, contactin 5, Gm507, HNB-2s, NB-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cntn5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Integrase zinc binding domain
- FN3
- immunoglobulin domain
- Integrase core domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- Fibronectin type 3 domain
- Integrase DNA binding domain
- Immunoglobulin V-set domain
- T-cell surface glycoprotein CD3 delta chain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- Huntington disease
- depressive disorder
- epithelial basal cell carcinoma
- epithelial cancer
- insomnia
- colorectal cancer
- major depression
- alcoholism
- diminished ovarian reserve
regulated by
- topotecan
role in cell
- activation in
- quantity
- assembly
- accumulation
- accumulation in
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- presynaptic membrane
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cntn5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- axon guidance
- brain development
Cellular Component
Where in the cell the gene product is active
- presynaptic membrane
- extracellular region
- plasma membrane
- axon