Nyap2 Gene Summary [Mouse]
Involved in neuron projection morphogenesis and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Is expressed in cortical plate. Orthologous to human NYAP2 (neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nyap2 |
| Official Name | neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 [Source:MGI Symbol;Acc:MGI:2443135] |
| Ensembl ID | ENSMUSG00000054976 |
| Bio databases IDs | |
| Aliases | neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2 |
| Synonyms | 9430031J16Rik, Jr6, KIAA1486, LOC100293817, neuronal tyrosine-phophorylated phosphoinositide 3-kinase adaptor 2, neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nyap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- peripheral neuropathy
- depressive disorder
- neuroticism
role in cell
- activation in
- binding in
- abnormal morphology
- morphogenesis
- remodeling
- remodeling in
- elongation in
- elongation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nyap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein kinase B signaling cascade
- neuron projection morphogenesis
Molecular Function
What the gene product does at the molecular level
- protein binding