Klc3 Gene Summary [Mouse]
Enables kinesin binding activity and microtubule binding activity. Involved in sperm mitochondrial sheath assembly. Acts upstream of or within axo-dendritic transport. Located in several cellular components, including ciliary rootlet; mitochondrion; and motile cilium. Is expressed in deep cerebellar nucleus; retina; and vestibular nucleus. Orthologous to human KLC3 (kinesin light chain 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klc3 |
| Official Name | kinesin light chain 3 [Source:MGI Symbol;Acc:MGI:1277971] |
| Ensembl ID | ENSMUSG00000040714 |
| Bio databases IDs | |
| Aliases | kinesin light chain 3 |
| Synonyms | BC017147, kinesin light chain 3, KLC2, KLC2L, KLCT, KNS2B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klc3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- microtubule binding
- Tetratricopeptide repeats
- protein binding
- tetratricopeptide repeat
- Cell division protein ZapB
- microtubule motor protein
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- motile cilia
- Mitochondria
- ciliary rootlet
- neurites
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Klc3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatid development
- axon cargo transport
- spermatogenesis
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- ciliary rootlet
- motile cilium
- cytoplasm
- mitochondrion
- kinesin complex
- neuron projection
- microtubule
Molecular Function
What the gene product does at the molecular level
- protein binding
- kinesin binding
- microtubule binding