KLC3 Gene Summary [Human]

This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
KLC3
Official Name
kinesin light chain 3 [Source:HGNC Symbol;Acc:HGNC:20717]
Ensembl ID
ENSG00000104892
Bio databases IDs NCBI: 147700 Ensembl: ENSG00000104892
Aliases kinesin light chain 3
Synonyms BC017147, kinesin light chain 3, KLC2, KLC2L, KLCT, KNS2B
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KLC3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • microtubule binding
  • Tetratricopeptide repeats
  • protein binding
  • tetratricopeptide repeat
  • Cell division protein ZapB
  • microtubule motor protein
  • kinesin binding

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • lung adenocarcinoma
  • lung adenocarcinoma formation
  • gastroesophageal reflux
regulated by
  • ETV6-RUNX1
  • metribolone
  • DNMT1
  • D-alpha-hydroxyglutarate
role in cell
  • development

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • motile cilia
  • Mitochondria
  • ciliary rootlet
  • neurites
  • photoreceptor inner segments

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human KLC3 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • spermatid development
  • axon cargo transport
  • spermatogenesis
  • microtubule-based movement

Cellular Component

Where in the cell the gene product is active
  • ciliary rootlet
  • motile cilium
  • cytoplasm
  • mitochondrion
  • kinesin complex
  • neuron projection
  • microtubule

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • kinesin binding
  • microtubule binding

Gene-Specific Assays for Results You Can Trust

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