Kcnk18 Gene Summary [Mouse]
Enables calcium-activated potassium channel activity. Involved in potassium ion transport and regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation. Located in plasma membrane. Is expressed in gut; male reproductive gland or organ; and olfactory lobe. Human ortholog(s) of this gene implicated in migraine. Orthologous to human KCNK18 (potassium two pore domain channel subfamily K member 18). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnk18 |
| Official Name | potassium channel, subfamily K, member 18 [Source:MGI Symbol;Acc:MGI:2685627] |
| Ensembl ID | ENSMUSG00000040901 |
| Bio databases IDs | |
| Aliases | potassium channel, subfamily K, member 18 |
| Synonyms | Gm781, K2p18.1, MGR13, potassium channel, subfamily K, member 18, potassium two pore domain channel subfamily K member 18, TRESK, TRESK-2, TRIK |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnk18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- outward rectifier potassium channel
- intracellular loop
- calcium-activated potassium channel
- protein binding
- ion channel
- PxIxIT motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnk18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transport
- potassium ion transmembrane transport
- cellular response to pH
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- outward rectifier potassium channel activity
- potassium ion leak channel activity