Adipor1 Gene Summary [Mouse]
This gene encodes a receptor for the fat-derived hormone adiponectin. Binding of adiponectin to the encoded protein results in activation of an AMP-activated kinase signaling pathway which affects levels of fatty acid oxidation and insulin sensitivity. Homozygous knockout mice for this gene exhibit elevated plasma glucose and insulin levels as well as impaired glucose tolerance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Adipor1 |
| Official Name | adiponectin receptor 1 [Source:MGI Symbol;Acc:MGI:1919924] |
| Ensembl ID | ENSMUSG00000026457 |
| Bio databases IDs | |
| Aliases | adiponectin receptor 1 |
| Synonyms | 2810031L11RIK, ACDCR1, adiponectin receptor 1, CGI-45, PAQR1, TESBP1A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adipor1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Haemolysin-III related
- hormone binding
- signaling receptor activity
- protein kinase binding
- intracellular domain
- channel protein, hemolysin III family
- protein-hormone receptor
- protein binding
- identical protein binding
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Adipor1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- Parkinson disease
- insulin resistance
- hyperglycemia
- diabetic nephropathy
- impaired glucose tolerance
- weight gain
phenotypes
- abnormal auditory brainstem response
- abnormal heart left ventricle morphology
- abnormal retina morphology
- abnormal retinal outer nuclear layer morphology
- decreased circulating alkaline phosphatase level
- decreased circulating calcium level
- decreased cornea thickness
- decreased exploration in new environment
- decreased hemoglobin content
- decreased lymphocyte cell number
- decreased total retina thickness
- increased blood urea nitrogen level
- increased circulating HDL cholesterol level
- increased circulating cholesterol level
- increased circulating creatinine level
- increased circulating phosphate level
- increased circulating triglyceride level
- increased neutrophil cell number
- increased red blood cell distribution width
- abnormal adaptive thermogenesis
- abnormal circulating HDL cholesterol level
- abnormal circulating alkaline phosphatase level
- abnormal circulating calcium level
- abnormal circulating cholesterol level
- abnormal circulating phosphate level
- abnormal circulating triglyceride level
- abnormal cornea thickness
- abnormal enzyme/coenzyme activity
- abnormal exploration in a new environment
- abnormal glucose homeostasis
- abnormal lipid homeostasis
- abnormal total retina thickness
- decreased adiponectin level
- decreased circulating adiponectin level
- decreased energy expenditure
- hyperglycemia
- hypoactivity
- impaired adaptive thermogenesis
- impaired glucose tolerance
- increased brown adipose tissue amount
- increased circulating glucose level
- increased circulating insulin level
- increased circulating leptin level
- increased liver triglyceride level
- increased percent body fat/body weight
- increased susceptibility to weight gain
- increased white adipose tissue amount
- insulin resistance
- no abnormal phenotype detected
role in cell
- proliferation
- apoptosis
- phosphorylation in
- expression in
- migration
- activation in
- cell viability
- quantity
- growth
- acetylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adipor1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of insulin receptor signaling pathway
- leptin-mediated signaling pathway
- negative regulation of JAK-STAT cascade
- positive regulation of JAK-STAT cascade
- hormone-mediated signaling pathway
- negative regulation of epithelial to mesenchymal transition
- regulation of glucose metabolic process
- fatty acid oxidation
- negative regulation of cell growth
- glucose homeostasis
- negative regulation of epithelial cell migration
- adiponectin-mediated signaling pathway
- regulation of lipid metabolic process
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- adipokinetic hormone receptor activity
- identical protein binding
- protein binding
- metal ion binding
- adiponectin binding
- signaling receptor activity